ome

新葡亰8883ent-welcome

| 设为首页 | 加入收藏

王家俊

时间:2019年12月19日 14:01 点击:

姓 名

王家俊

性 别

 

出生年月

1989.10

民 族

汉族

职 称

副教授

学 位

博士

办公电话


职 务


所 属 系

动物营养与饲料科学

E--mail

wjj1989@neau.edu.cn

研究方向

功能性饲料添加剂研发

个人简历

1.教育状况

2008.09-2012.06:东北农业大学动物科学专业,学士

2012.09-2015.06:东北农业大学动物营养与饲料科学专业,硕士

2015.09-2019.06:东北农业大学动物营养与饲料科学专业,博士

2.工作经历

2019.09-至今:东北农业大学新葡亰8883ent,副教授

3.代表性论文(第一作者或并列第一作者)

  1. Jiajun Wang, Xiujing Dou, Jing Song, Yinfeng Lyu, Xin Zhu, Lin Xu, Weizhong Li, Anshan Shan*, Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era[J], Medicinal Research Reviews , 2019, 39(3): 831-859. (IF2020=12.944, 中科院分区(升级)2019一区Top, 热点文章)

  2. Jing Song#, Jiajun Wang#, Na Zhan, Taotao Sun, Weikang Yu, Licong Zhang, Anshan Shan*, and Aizhong Zhang, Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging, ACS Applied Materials & Interfaces, 2019, 11(47): 43820-43834.(共同第一作者,IF2020=9.229, 中科院分区(升级)2019一区Top)

  3. Jiajun Wang#, Jing Song#, Zhanyi Yang, Shiqi He, Yi Yang, Xingjun Feng, Xiujing Dou, Anshan Shan*, Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria[J], Journal of Medicinal Chemistry, 2019, 62(5): 2286-2304. (IF2020=7.446, 中科院分区(升级)2019一区Top)

  4. Shuli Chou#, Jiajun Wang#, Lu Shang, M.U. Akhtar, Zhihua Wang, Baoming Shi, Xingjun Feng, Anshan Shan*, Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity[J]. Biomaterials Science, 2019, 7(6): 2394-2409.(共同第一作者, IF2020=6.843, 中科院分区(升级)2019二区)

  5. Jiajun Wang#, Shuli Chou#, Zhanyi Yang, Yang Yang, Zhihua Wang, Jing Song, Xiujing Dou, Anshan Shan*, Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides[J], Journal of Medicinal Chemistry, 2018, 61(9): 3889-3907. (IF2020=7.446, 中科院分区2019Top)

  6. Jiajun Wang, Shuli Chou, Li Xu, Xin Zhu, Na Dong, Anshan Shan*, Zhihui Chen, High specific selectivity and membrane-active mechanism of the synthetic centrosymmetric alpha-helical peptides with Gly-Gly pairs[J]. Scientific Reports, 2015, 5: 15963.(IF2015=5.228, 中科院分区2015)

  7. Yang Yang, Wang Chenxi, Gao Nan, Lyu Yinfeng, Zhang Licong, Zhang Sujiang, Wang Jiajun*, Shan Anshan*. A Novel Dual-Targeted α-Helical Peptide with Potent Antifungal Activity Against Fluconazole-Resistant Candida albicans Clinical Isolates[J]. Frontiers in Microbiology, 2020, 11(2386). IF2020=5.64,中科院分区(升级)2020二区Top

  8. He Shiqi, Yang Zhanyi, Yu Weikang, Li Jiawei, Li Zhongyu, Wang Jiajun*, Shan Anshan*. Systematically Studying the Optimal Amino Acid Distribution Patterns of the Amphiphilic Structure by Using the Ultrashort Amphiphiles[J]. Frontiers in Microbiology,2020, 11:569118. IF2020=5.64,中科院分区(升级)2020二区Top.

  9. Li Qiuke, Li Jinze, Yu Weikang, Wang Zhihua, Li Jiawei, Feng Xingjun, Wang Jiajun *, Shan Anshan*. De novo design of a pH-triggered self-assembled β-hairpin nanopeptide with the dual biological functions for antibacterial and entrapment. Journal of Nanobiotechnology 19, 183 (2021). (IF2020 = 10.435, 中科院分区(升级)2021二区,中科院分区2021一区top)

  10. Yu Weikang#, Wang Jiajun#, Wang Zihang, Li Lingxue, Li Wenyu, Song Jing, Zhang Shanshan, Shan Anshan. PEGylation of the Antimicrobial Peptide PG-1: A Link between Propensity for Nanostructuring and Capacity of the Antitrypsin Hydrolytic Ability[J]. Journal of medicinal chemistry, 2021, 64(14): 10469-10481. (共同一作,IF2020=7.446, 中科院分区(升级)2021一区Top)

  11. 于伟康,张珊珊,杨占一,王家俊*,单安山*.超分子多肽自组装在生物医学中的应用[J].生物工程学报,2021,37(07):2240-2255. DOI: 10.13345/j.cjb.200440.

  12. Yang Zhanyi, He Shiqi, Wang Jiajun, Yang Yi, Zhang Licong, Li Yanbing, Shan Anshan*, Rational design of short peptide variants by using Kunitzin-RE, an amphibian-derived bioactivity peptide, for acquired potent broad-spectrum antimicrobial and improved therapeutic potential of commensalism coinfection of pathogens[J], Journal of Medicinal Chemistry, 2019, 62(9): 4586-4605. (IF2019=6.205, 中科院分区(升级)2019一区Top)

  13. Xiujing Dou, Xin Zhu, Jiajun Wang, Na Dong, Anshan Shan*, Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism[J], Journal of Medicinal Chemistry, 2017, 60(6): 2257-2270. (IF2017=6.253, 中科院分区2019一区Top)

  14. Shuli Chou, Changxuan Shao, Jiajun Wang, Anshan Shan*, Lin Xu, Na Dong, Zhongyu Li, Short, multiple-stranded beta-hairpin peptides have antimicrobial potency with high selectivity and salt resistance[J], Acta Biomaterialia, 2016, 30: 78-93. (IF2016=6.319, 中科院分区2016一区Top)

  15. Zhu Xin, Shan Anshan*, Ma Zhi, Xu Wei, Wang Jiajun, Chou Shuli, Cheng Baojing, Bactericidal efficiency and modes of action of the novel antimicrobial peptide T9W against Pseudomonas aeruginosa[J], Antimicrobial Agents & Chemotherapy, 2015, 59(6): 3008-3017.IF2015=4.415, 中科院分区2015二区TOP

  16. Xu, Lin, Chou, Shuli, Wang, Jiajun, Shao, Changxuan, Li, Weizhong, Zhu, Xin, Shan, Anshan*, Antimicrobial activity and membrane-active mechanism of tryptophan zipper-like beta-hairpin antimicrobial peptides[J], Amino acids, 2015, 47(11): 2385-2397.IF2015=3.196中科院分区2015二区)

  17. Lv Yinfeng, Wang Jiajun, Gao He, Wang Zeyun, Dong Na, Ma Qingquan, Shan Anshan*, Antimicrobial properties and membrane-active mechanism of a potential alpha-helical antimicrobial derived from cathelicidin PMAP-36[J], Plos One, 2014, 9(1): e86364.IF2014=3.234, 中科院分区2014三区)

  18. Zhu Xin, Ma Zhi, Wang Jiajun, Chou Shuli, Shan Anshan*, Importance of tryptophan in transforming an amphipathic peptide into a Pseudomonas aeruginosa-targeted antimicrobial peptide[J], Plos One, 2013, 9(12): e114605.IF2013=3.785, 中科院分区2013三区)

  19. 徐博成, 王家俊, 丑淑丽, 单安山*. 细菌对抗菌肽的抗性及机理[J]. 动物营养学报, 2017, 29(6): 1874-1883.

  20. Chensi WangChangxuan ShaoYuxin FangJiajun WangNa DongAnshan Shan. Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides. Acta Biomaterialia.2021. 124254-269. 8.947 一区top IF=8.947

  21. Li Jia Wei, Shang Lu, Lan Jing, Chou Shu Li, Feng Xing Jun, Shi Bao Ming, Wang JiaJun, Lyu YinFeng, Shan AnShan. Targeted and Intracellular Antibacterial Activity against S. agalactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides[J]. ACS applied materials & interfaces, 2020, 12(40): 44459-44474.

  22. Xu Lin, Shao Changxuan, Li Guoyu, Shan Anshan, Chou Shuli, Wang Jiajun, Ma Qingquan, Dong Na. Conversion of Broad-Spectrum Antimicrobial Peptides into Species-Specific Antimicrobials Capable of Precisely Targeting Pathogenic Bacteria[J]. Scientific Reports, 2020, 10(1): 944.

  23. Zhan N., Zhang L. C., Yang H., Zheng Y. L., Wei X. K., Wang J. J., Shan A. S. Design and heterologous expression of a novel dimeric LL37 variant in Pichia pastoris[J]. Microbial Cell Factories, 2021, 20(1): 13.

  24. 张珊珊,宋静,王家俊,单安山*.细菌生物膜的形成及抗菌肽抗生物膜活性的研究进展.动物营养学报.2021

 

4. 专利

1一种尾端锚定的α螺旋抗菌肽GW4A及制备方法和应用2201910659907.1(已授权)

2、一种靶向真菌的抗菌肽及制备方法和应用(1),202111298404X

3、一种广谱抗菌的α螺旋肽及其制备方法和应用(1),2021111912311.1

4、基于两栖类蛙源抗菌肽的衍生肽W8及其制备方法和应用4 201811452513.0(已授权)

5一种靶向抗菌肽及其制备方法和应用4 201611052825.3 (已授权)

6、一种非完美两亲性肽W4及其制备方法和应用4 201811452528.7(已授权)

 

5. 在研课题

主持课题

1.“东农学者”学术骨干项目(人才引进)19YJXG05,《疏水性氨基酸尾端锚定结构对抗菌肽生物学活性的影响》,主持人(30万,20190901-20220901

2.黑龙江省自然科学基金优秀青年项目:YQ2020C009,《抗酶解β-折叠肽的全新设计及其对腹泻断奶仔猪肠道健康的影响》,主持人10万,20200701-20230701Natural Science Foundation of Heilongjiang Province of China

3. 国家自然科学基金青年科学基金项目:32002215《高稳定脂酰肽的分子设计、纳米组装体构建及猪肠道内抗菌效力研究》,主持人(24万,20210101-20231231National Natural Science Foundation of China

4. 国家自然科学基金重点项目:32030101,猪饲用型抗菌肽的研究,第二参与人(300万,20210101-20251231

5. 中国博士后面上项目(二等)2021M690576, 《抗酶解型Trp富集肽的分子设计、构效关系及抗菌机制研究8万,202106-202306

6. 黑龙江省博士后面上项目(一等):LBH-Z21003,《脂酰化富脯氨酸肽分子的全新设计、纳米组装体构建及其体内应用效果研究》(10万, 202112-202312

 

参与课题:

1. 国家自然科学基金委员会,面上项目,31672434,靶向抗菌肽的分子设计、表达及应用研究,2017-012020-1266万元,在研,参加7

2. 国家自然科学基金委员会,青年项目,31802100,苯基丁酸钠调控猪源宿主防御肽转录与合成的分子机制,2019-012022-1226万元,在研,参加5

3. 国家自然科学基金委员会,面上项目,31772611,亮氨酸对猪脂肪细胞代谢和脂肪沉积的影响及机制,2018-012021-1261万元,在研,参加

4.黑龙江省自然基金面上项目:《组氨酸去乙酰化抑制对猪源抗菌肽表达调控的分子机制(C2018028),第四参与人

6. 获奖情况

12020年度帝斯曼缤纷科技奖动物营养科学青年学者奖-优胜奖

22021年度黑龙江省研究生导学思政团队(导师)-- 非粮型饲料资源研发研究生导学思政团队

 

 

上一篇:孟庆维

下一篇:孙浩洋

关闭